Toxicology: Long-Term Co-Perfused 3D Human Organoid Liver Hollow Fiber Model for Heaptotoxicity

Long-term co-perfused 3D human organoid liver hollow fiber model for hepatoxoticity

3D human liver organoid combined with hollow fiber system, clinical biochemical tests and next generation sequencing (NGS)
Use of Tylenol or N-acetyl-para-aminophenol (APAP) concentrations known to cause drug induced liver injury in the clinic by the Rumack-Matthews monogram
Investigated effect of increasing the dose of pyrazinamide on liver injury with APAP as positive control
Effects measured using clinical tests, enzyme and cytokine assays, and RNA-seq
Examined over a 4 week period of daily doses with concentration- time profiles similar to patients

Research Paper: A Long Term Co-perfused Disseminated Tuberculosis-3D Liver Hollow Fiber Model for Both Drug Efficacy and Hepatotoxicity in Babies

Shashikant Srivastava^a, Jotam G. Pasipanodya^a, Geetha Ramachandran^b, Devyani Deshpande^a, Stephen Shuford^c, Howland E. Crosswell^c, Kayle N. Cirrincione^a, Carleton M. Sherman^a, Soumya Swaminathan^b, Tawanda Gumbo^a,b*

Content list available at Science Direct: VIEW HERE

EBioMedicine Journal: VIEW HERE

HFS

Toxicology: Long-Term Co-Perfused 3D Human Organoid Liver Hollow Fiber Model for Heaptotoxicity

Toxicology: Long-Term Co-Perfused 3D Human Organoid Liver Hollow Fiber Model for Heaptotoxicity

Long-term co-perfused 3D human organoid liver hollow fiber model for hepatoxoticity

Research Paper: A Long Term Co-perfused Disseminated Tuberculosis-3D Liver Hollow Fiber Model for Both Drug Efficacy and Hepatotoxicity in Babies

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