Toxicology: Long-Term Co-Perfused 3D Human Organoid Liver Hollow Fiber Model for Heaptotoxicity
Long-term co-perfused 3D human organoid liver hollow fiber model for hepatoxoticity
- 3D human liver organoid combined with hollow fiber system, clinical biochemical tests and next generation sequencing (NGS)
- Use of Tylenol or N-acetyl-para-aminophenol (APAP) concentrations known to cause drug induced liver injury in the clinic by the Rumack-Matthews monogram
- Investigated effect of increasing the dose of pyrazinamide on liver injury with APAP as positive control
- Effects measured using clinical tests, enzyme and cytokine assays, and RNA-seq
- Examined over a 4 week period of daily doses with concentration- time profiles similar to patients
Research Paper: A Long Term Co-perfused Disseminated Tuberculosis-3D Liver Hollow Fiber Model for Both Drug Efficacy and Hepatotoxicity in Babies

