Toxicology: Long-Term Co-Perfused 3D Human Organoid Liver Hollow Fiber Model for Heaptotoxicity

Long-term co-perfused 3D human organoid liver hollow fiber model for hepatoxoticity

  • 3D human liver organoid combined with hollow fiber system, clinical biochemical tests and next generation sequencing (NGS)
  • Use of Tylenol or N-acetyl-para-aminophenol (APAP) concentrations known to cause drug induced liver injury in the clinic by the Rumack-Matthews monogram
  • Investigated effect of increasing the dose of pyrazinamide on liver injury with APAP as positive control
  • Effects measured using clinical tests, enzyme and cytokine assays, and RNA-seq
  • Examined over a 4 week period of daily doses with concentration- time profiles similar to patients

Research Paper: A Long Term Co-perfused Disseminated Tuberculosis-3D Liver Hollow Fiber Model for Both Drug Efficacy and Hepatotoxicity in Babies

Shashikant Srivastavaa, Jotam G. Pasipanodyaa, Geetha Ramachandranb, Devyani Deshpandea, Stephen Shufordc, Howland E. Crosswellc, Kayle N. Cirrincionea, Carleton M. Shermana, Soumya Swaminathanb, Tawanda Gumboa,b*

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