Rapid Testing of Cancer Leads Through to Clinical Testing Phase

Use of Hollow Fiber System & predicted human concentrations time profiles to determine efficacy of several drug leads (antibody guided liposomes carrying small molecules):

  • Non-small cell lung cancer (NSCLC) line H2342
  • Ovarian cancer cell line (OAW28)
  • Colorectal cancer (HT29)

Dose response studies and dose scheduling studies to find optimal dose, optimal dosing schedule and predict human concentration time profiles.

Using NGS in combination with effect to establish several novel mechanisms of efficacy.

Examination of equipotency for different formulations of leads.

Results presented as part of IND submission, leading to approval of several of the leads that are now ready for clinical testing.

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