Discovery to CMC
Pharmaceutics. Development of analytical methods & prototype formulations & testing efficacy of formulations. Impurity identification. Solubility assessment. Stability testing. Permeability into cells. Off target screening using ‘omics. Cytotoxicity. Chemistry, Manufacture and Control (CMC). ADME.
Hollow Fiber Model
Client customized hollow fiber system (HFS) models with and without 3D human organotypic models, HFS with a full human immune system, PBMCs and next generation post-HFS preclinical model studies.
Case Studies
View Praedicare's case studies on cancer, human immune system based responses, toxicology with 3D human organotypic models, viruses, fungal infection, protozoa, rapidly growing and slow growing mycobacteria, Gram-positive and Gram-negative bacteria.
Hollow Fiber Model
Client customized hollow fiber system (HFS) models with and without 3D human organotypic models, PBMCs, and next generation post-HFS preclinical model studies.

Design of combination regimens to find best drugs and best doses to combine, using factorial design and human-based pharmacokinetics.
HFS-TB CASE STUDIES
VIEW OUR CASE STUDIES
TB Combination Regimens
Pre-clinical HFS models, combination regimens and clinical translation
Non-Tuberculosis Mycobacterium Combination Regimens
Pre-clinical HFS models, combination regimens and clinical translation
Pre-clinical HFS models, including with a bone marrow, advanced DNA-seq, methylation, and RNA-seq, combination regimens and clinical translation
Pre-clinical HFS models, 3D human organotypic models, advanced multi-omics, database of known clinical toxins and machine learning
Pre-clinical HFS models, 3D human organotypic models, LC/MS/MS quantitation Nonlinear dynamical sink models to map physiological and pathological pathways to organ anatomy and drug concentrations based on 3D human organoids, human pathology samples and biopsies